What’s the best bet to make, considering each of the 14 matchups on the NFL’s Week 10 slate? Our favorite point-spread choice is Buccaneers +5.5, but we have lots more suggestions for you, which could lead to parlay opportunities, below.

Take advantage of our predictions to make your NFL picks this week. BetMGM has all the information you need to begin betting on the NFL.

Best Week 10 Spread Bets

Jump to Matchup:

NYJ-ARI | MIA-LAR | PIT-WAS | ATL-NO | DET-HOU

Pick: Cardinals -1 vs. Jets

• Matchup: New York Jets at Arizona Cardinals
• Projected Winner & Margin: Cardinals by 11.7 points (Bet on this game at BetMGM)
• Spread: Cardinals -1
• Time: 4:25 p.m. ET
• Date: Nov. 10
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Rams -2.5 vs. Dolphins

• Matchup: Miami Dolphins at Los Angeles Rams
• Projected Winner & Margin: Rams by 16.7 points (Bet on this game at BetMGM)
• Spread: Rams -2.5
• Time: 8:15 p.m. ET
• Date: Nov. 11
• TV Channel: ESPN
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Commanders -3 vs. Steelers

• Matchup: Pittsburgh Steelers at Washington Commanders
• Projected Winner & Margin: Commanders by 4.7 points (Bet on this game at BetMGM)
• Spread: Commanders -3
• Time: 1 p.m. ET
• Date: Nov. 10
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Pick: Falcons -3.5 vs. Saints

• Matchup: Atlanta Falcons at New Orleans Saints
• Projected Winner & Margin: Falcons by 5.3 points (Bet on this game at BetMGM)
• Spread: Falcons -3.5
• Time: 1 p.m. ET
• Date: Nov. 10
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Pick: Lions -3.5 vs. Texans

• Matchup: Detroit Lions at Houston Texans
• Projected Winner & Margin: Lions by 8.3 points (Bet on this game at BetMGM)
• Spread: Lions -3.5
• Time: 8:20 p.m. ET
• Date: Nov. 10
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Make smart decisions. Use those stats when making your NFL picks and place your bet on BetMGM.

Best Week 10 Total Bets

Jump to Matchup:

Under 49 – Lions vs. Texans

• Matchup: Detroit Lions at Houston Texans
• Projected Total: 47.7 points (Bet on this game at BetMGM)
• Time: 8:20 p.m. ET
• Date: Nov. 10
• TV Channel: NBC
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 45.5 – Steelers vs. Commanders

• Matchup: Pittsburgh Steelers at Washington Commanders
• Projected Total: 44.2 points (Bet on this game at BetMGM)
• Time: 1 p.m. ET
• Date: Nov. 10
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Under 41.5 – Broncos vs. Chiefs

• Matchup: Denver Broncos at Kansas City Chiefs
• Projected Total: 41.0 points (Bet on this game at BetMGM)
• Time: 1 p.m. ET
• Date: Nov. 10
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Over 50.5 – 49ers vs. Buccaneers

• Matchup: San Francisco 49ers at Tampa Bay Buccaneers
• Projected Total: 52.4 points (Bet on this game at BetMGM)
• Time: 1 p.m. ET
• Date: Nov. 10
• TV Channel: FOX
• Live Stream: Watch this game on Fubo (Regional restrictions may apply)

Under 46 – Bills vs. Colts

• Matchup: Buffalo Bills at Indianapolis Colts
• Projected Total: 45.2 points (Bet on this game at BetMGM)
• Time: 1 p.m. ET
• Date: Nov. 10
• TV Channel: CBS
• Live Stream: Paramount+ | Fubo (Regional restrictions may apply)

Catch every NFL touchdown with NFL RedZone on Fubo.

Not all offers available in all states, please visit BetMGM for the latest promotions for your area. Must be 21+ to gamble, please wager responsibly. If you or someone you know has a gambling problem, contact 1-800-GAMBLER.